Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy

    • Zaloguj
    Zobacz pozycję 
    •   Strona główna Repozytorium
    • PIWet - PIB
    • Publikacje
    • Zobacz pozycję
    •   Strona główna Repozytorium
    • PIWet - PIB
    • Publikacje
    • Zobacz pozycję
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Assessment of the (anti)androgenic potential of three organophosphate esters using the recombinant yeast androgen bioassay

    Toxicology Letters

    Thumbnail
    Data
    2024
    Autor
    Stypuła-Trębas, Sylwia
    Jedziniak, Piotr
    Metadane
    Pokaż pełny rekord
    Streszczenie
    Organophosphate esters (OPEs) are synthetic phosphoric acid derivatives widely used as flame retardants, plasticizers, and lubricants. In recent years, the production of OPEs has rapidly increased. This is due to the withdrawal of brominated flame retardants, as well as the lack of regulation on OPEs usage limits. The presence of OPEs has been detected in various environmental matrices and biota. Also, the estimated daily intake of the sum of the eight most common OPEs is high, especially in toddlers (1.547 μg/kg b.w./day). Earlier toxicological studies have demonstrated that OPEs can cause various adverse toxic effects, including neurotoxicity, genotoxicity, and nephrotoxicity. The risk associated with exposure to OPEs is intensified by the fact that these substances accumulate in adipose tissue, which hinders their rapid metabolism. Recent toxicity tests indicate potential reproductive and developmental toxicity and hormonal activity in humans and animals. Since hormonally active compounds may cause harmful health effects, there is a need to identify their mechanism(s) of action. In this study, we examined (anti)androgenic activity of three commonly used OPEs.
    URI
    https://www.sciencedirect.com/science/article/abs/pii/S0378427424018757?via%3Dihub
    Zbiory
    • Publikacje [643]

    DSpace software copyright © 2002-2016  DuraSpace
    Kontakt z nami | Wyślij uwagi
    Theme by 
    Atmire NV
     

     

    Przeglądaj

    Całe RepozytoriumZbiory i kolekcjeDaty wydaniaAutorzyTytułyTematyTa kolekcjaDaty wydaniaAutorzyTytułyTematy

    Moje konto

    Zaloguj

    Statystyki

    Przejrzyj statystyki użycia

    DSpace software copyright © 2002-2016  DuraSpace
    Kontakt z nami | Wyślij uwagi
    Theme by 
    Atmire NV